Christophe Chipot  
Centre National de la Recherche Scientifique Research Director

Phone :     +33-(0)3-83-68-40-97
Fax :         +33-(0)3-83-68-40-97
E-mail : and

Biographical sketch
Christophe Chipot was born in Paris, France in 1967. In 1990, he received a M.Sc. in Physical Chemistry from the University of Nancy. In 1994, he obtained a Ph.D. in Theoretical Chemistry from the University of Nancy under the direction of Bernard Maigret. He subsequently joined the group of Peter Kollman at the University of California, San Francisco. He then moved to the NASA Ames Research Center, where he investigated interfacial phenomena with Andrew Pohorille. In 1996, he was recruited by the Centre National de la Recherche Scientifique, and obtained his habilitation in 2000. Since 2006, he has held the position of Research Director at the University of Nancy with a joint appointment at the University of Illinois, Urbana-Champaign. His research interests range from the structure and function of membrane proteins to developments of intermolecular potentials as well as new strategies for free-energy calculations.

Research areas
Modeling of protein-membrane interaction, free-energy calculations in biological systems, and development of intermolecular interaction potentials.

Scientific production
141 publications in peer-reviewed journals. 13 book chapters. 1 book. 54 invited talks in international conferences. h-index 41, i10-index 108, 14,140 cumulated citations.

Selected publications
  1. Gumbart, J. C.; Roux, B.; Chipot, C. Efficient determination of protein-protein standard binding free energies from first principles. J. Chem. Theor. Comput., 2013, 9, 3789-3798.
  2. Chandler, D.; Penin, F.; Schulten, K.; Chipot, C. The p7 protein of Hepatitis C forms structurally plastic ion channels. PLoS Comput. Biol., 2012, 8, e1002702
  3. Gumbart, J. Chipot, C. ; Schulten, K. Free-energy cost for translocon-assisted insertion of membrane proteins. Proc. Natl. Acad. of Sciences, USA, 2011, 108, 3596-3601.
  4. Pohorille, A.; Jarzynski, C.; Chipot, C. Good practices in free-energy calculations. J. Phys. Chem. B, 2010, 114, 10235-10253 .
  5. Phillips, J. C.; Braun, R.; Wang, W.; Gumbart, J.; Tajkhorshid, E.; Villa, E.; Chipot, C.; Skeel, L.; Schulten, K., Scalable molecular dynamics with NAMD. J. Comput. Chem. 2005, 26, 1781-1802.

Recent publications

Bignon, E.; Gattuso, H.; Morell, C.; Dehez, F.; Georgakilas, A. G.; Monari, A. & Dumont, E.
Correlation of bistranded clustered abasic DNA lesion processing with structural and dynamic DNA helix distortion.
Nucleic Acids Res.

2016,  (44), 8588-8599.

Wang, S.; Zhao, T.; Shao, X.; Chipot, C.; Cai, W.
Complex movements in rotaxanes: Shuttling coupled with conformational transition of cyclodextrins
J. Phys. Chem. C

2016,  (120), 19479-19486.

Gattuso, H.; Durand, E.; Bignon, E.; Morell, C.; Georgakilas, A. G.; Dumont, E.; Chipot, C.; Dehez, F.; Monari, A.
Repair rate of clustered abasic DNA lesions by human endonuclease: Molecular bases of sequence specificity
J. Phys. Chem. Lett

2016,  (19), 3760-3765.


- Renewal of the Laboratoire International Associé CNRS-University of Illinois at Urbana-Champaign on November 2016
- An update of ParseFEP is available in the latest version of VMD.
- 新的分子动力学讲义 (Dissemination).


Laboratoire International Associé
Unité mixte de recherche n°7565
Université de Lorraine, B.P. 70239
54506 Vandoeuvre-lès-Nancy Cedex, France
Phone: +33.(0)
Fax: +33.(0)
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